Idalopirdine (Lu AE58054) 是有效，选择性的 5-HT6 受体拮抗剂，Ki 为 0.83 nM。
| Cas No. | 467459-31-0 |
| 别名 | Lu AE58054 |
| Canonical SMILES | FC1=CC(NC=C2CCNCC3=CC(OCC(F)(C(F)F)F)=CC=C3)=C2C=C1 |
| 分子式 | C20H19F5N2O |
| 分子量 | 398.37 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Idalopirdine (Lu AE58054) is a potent and selective 5-HT6 receptor antagonist with a Ki of 0.83 nM. [1]. Arnt J, Bang-Andersen B, Grayson B, Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats. Int J Neuropsychopharmacol. 2010 Sep;13(8):1021-33.
[2]. Witten L, Bang-Andersen B, Nielsen SM, Characterization of [•H]Lu AE60157 ([•H]8-(4-methylpiperazin-1-yl)-3-phenylsulfonylquinoline) binding to 5-hydroxytryptamine• (5-HT•) receptors in vivo.Eur J Pharmacol. 2012 Feb 15;676(1-3):6-11. |
