| 包装: | 500µg |
| 市场价: | 2253元 |
| Canonical SMILES | O=P(O[C@H]1[C@@H](O)[C@@](N2C(NC(N)=NC3=O)=C3N=C2)([H])O[C@@H]1COP([O-])([O-])=O)([O-])OC[C@@H]4[C@@H](O)[C@@H](O)[C@@](N5C(NC(N)=NC6=O)=C6N=C5)([H])O4.[Na+].[Na+].[Na+] |
| 分子式 | C20H23N10O15P2•3Na |
| 分子量 | 774.4 |
| 溶解度 | Water: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 5'-pGpG is a linearized form of cyclic di-GMP, a bacterial second messenger that activates the host innate immune system through stimulator of interferon genes (STING).1,2,3It is a metabolite of cyclic di-GMP formedviahydrolysis by various phosphodiesterases (PDEs) that binds to the cyclic di-GMP-I riboswitch with reduced affinity compared to cyclic di-GMP.4,55'-pGpG is intended for use as a negative control for cyclic di-GMP signaling. 1.Burdette, D.L., Monroe, K.M., Sotelo-Troha, K., et al.STING is a direct innate immune sensor of cyclic-di-GMPNature478(7370)515-518(2011) 2.Parvatiyar, K., Zhang, Z., Teles, R.M., et al.DDX41 recognizes bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune responseNat. Immunol.13(12)1155-1161(2012) 3.RÖmling, U., Galperin, M.Y., and Gomelsky, M.Cyclic di-GMP: The first 25 years of a universal bacterial second messengerMicrobiol. Mol. Biol. Rev.77(1)1-52(2013) 4.RÖmling, U., Galperin, M.Y., and Gomelsky, M.Cyclic di-GMP: The first 25 years of a universal bacterial second messengerMicrobiol. Mol. Biol. Rev.77(1)1-52(2013) 5.Smith, K.D., Lipchock, S.V., and Strobel, S.A.Structural and biochemical characterization of linear dinucleotide analogues bound to the c-di-GMP-I aptamerBiochemistry51(1)425-432(2012) |
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