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LY2183240 2'-isomer
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LY2183240 2'-isomer图片
CAS NO:1010096-65-7
包装与价格:
包装价格(元)
1mg询价
5mg询价
10mg询价

Cas No.1010096-65-7
别名5-([1,1'-联苯]-4-基甲基)-N,N-二甲基-2H-四唑-2-甲酰胺
Canonical SMILESO=C(N(C)C)N1N=NC(CC(C=C2)=CC=C2C3=CC=CC=C3)=N1
分子式C17H17N5O
分子量307.4
溶解度DMF: 3 mg/ml,DMSO: 2 mg/ml,Ethanol: 10 mg/ml,Ethanol:PBS(pH 7.2) (1:5): 0.1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

LY2183240 is a potent, competitive small molecule inhibitor of anandamide uptake (IC50 = 270 pM; Ki = 540 pM) and hydrolysis. It has been shown to increase anandamide levels in rat cerebellum (ED50 = 1.37 mg/kg) and displays dose-dependent efficacy (3-30 mg/kg) in several rodent models of persistent pain. LY2183240 2'-isomer is a less potent, 2,5-regioisomer of LY2183240 that inhibits anandamide hydrolysis and uptake with IC50 values of 33 and 998 nM, respectively.

 
 
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