生物活性
SANT-1是有效的细胞渗透性Sonic刺猬（Shh）信号传导抑制剂；平滑活性的高亲和力拮抗剂（KD = 1.2 nM）。以20 nM的IC50抑制平滑的激动剂作用（在Shh-LIGHT2细胞中）。
靶点信息
| Smoothened receptor | | | | |
| 1.2 nM(Kd) | | | | |
化学数据
| 目录号 | A13095 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 373.5 |
| Formula | C23H27N5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 304909-07-7 |
| Synonyms | SANT 1, SANT1 |
| SMILES | CC1=C(C(=NN1C2=CC=CC=C2)C)/C=N/N3CCN(CC3)CC4=CC=CC=C4 |
溶解度
| In vitro | DMSO | 21 mg/mL (56.22 mM) |
| Water | Insoluble |
| Ethanol | 20 mg/mL (53.54 mM) |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 26.77 mL | 133.87 mL | 267.74 mL |
| 0.5 mM | 5.35 mL | 26.77 mL | 53.55 mL |
| 1 mM | 2.68 mL | 13.39 mL | 26.77 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.35 mL |
*The above data is based on the productmolecular weight 373.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
