硝苯地平 D6 (BAY-a-1040 D6) 是氘标记的硝苯地平，硝苯地平是一种有效的钙通道阻滞剂。
| Cas No. | 1188266-14-9 |
| 别名 | 硝苯地平 D6; BAY-a-1040-d6 |
| Canonical SMILES | CC1=C(C(OC([2H])([2H])[2H])=O)C(C(C(OC([2H])([2H])[2H])=O)=C(C)N1)C2=CC=CC=C2[N+]([O-])=O |
| 分子式 | C17H12D6N2O6 |
| 分子量 | 352.4 |
| 溶解度 | Chloroform: Slightly Soluble,Methanol: Slightly Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Nifedipine-d6 is intended for use as an internal standard for the quantification of nifedipine by GC- or LC-MS. Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 μM. Nifedipine (1 μM) reduces TGF-β-induced calcium oscillations in human fibroblasts and prevents impairment of lung function in a mouse model of pulmonary fibrosis induced by bleomycin when administered at a dose of 10 mg/kg per day. It also reduces increases in mean arterial blood pressure induced by angiotensin II in spontaneously hypertensive rats when administered at a dose of 10 μg/kg. Formulations containing nifedipine have been used in the treatment of hypertension and angina. |
