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D-3263 hydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
D-3263 hydrochloride图片
CAS NO:1008763-54-9
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)询价
1mg询价
5mg询价
10mg询价
50mg询价
100mg询价

D-3263hydrochloride是一种可口服的TRPM8激动剂。
Cas No.1008763-54-9
Canonical SMILES[H]Cl.O=C1N(CCN)C2=CC(OC)=CC=C2N1C([C@H]3[C@H](C(C)C)CC[C@@H](C)C3)=O
分子式C21H32ClN3O3
分子量409.95
溶解度DMSO : ≥ 40 mg/mL (97.57 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

D-3263 hydrochloride is an enteric-coated, orally bioavailable (transient receptor potential melastatin member 8) TRPM8 agonist.

D-3263 hydrochloride binds to and activates TRPM8, which may result in an increase in calcium and sodium entry; the disruption of calcium and sodium homeostasis; and the induction of cell death in TRPM8-expressing tumor cells. D-3263 hydrochloride may decrease dihydrotestosterone (DHT) levels, which may contribute to its inhibitory effects on prostate cancer and BPH[1].

[1]. enteric-coated TRPM8 agonist D-3263 hydrochloride

 
 
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