| CAS： | 1225037-39-7 |
| 分子式： | C17H20F3N7O2 |
| 分子量： | 411.38 |
| 纯度： | >98% |
| 溶解性： | DMSO |
| 存储： | Powder -20℃ 3 years; 4℃ 2 years In solvent -80℃ 6 months;-20℃ 1 month |
| 研究领域： | Cancer |
| Target： | PI3Kα, 33 nM; PI3Kβ, 661 nM; PI3Kδ, 451 nM; PI3Kγ, 708 nM; PI3Kα-H1047R, 36 nM; PI3Kα-E545K, 136 nM; PI3Kα-E542K, 63 nM; Vps34, 6486 nM; mTOR, 89 nM; mTORC1, mTORC2, DNA-PK, 8567 nM |
| 描述： | Bimiralisib (PQR309) is a potent, brain-penetrant, orally bioavailable, pan-class I PI3K/mTOR inhibitor with IC50s of 33 nM, 451 nM, 661 nM, 708 nM and 89 nM for PI3Kα, PI3Kδ, PI3Kβ, PI3Kγ and mTOR, r |
