Catharanthine 是一种从马达加斯加长春花中分离出来的生物碱，抑制电压操作的 L 型 Ca2+ 通道，具有抗癌和降血压活性。
| Cas No. | 2468-21-5 |
| 别名 | 长春质碱; (+)-3,4-Didehydrocoronaridine |
| 化学名 | (6R,6aR,9S)-methyl 7-ethyl-6,6a,9,10,12,13-hexahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-6-carboxylate |
| Canonical SMILES | O=C([C@@]1(C(N([H])C2=C([H])C([H])=C([H])C([H])=C32)=C3C([H])([H])C4([H])[H])[C@](C(C([H])([H])C([H])([H])[H])=C5[H])([H])N4C([H])([H])[C@@]5([H])C1([H])[H])OC([H])([H])[H] |
| 分子式 | C21H24N2O2 |
| 分子量 | 336.42 |
| 溶解度 | ≥ 16.821mg/mL in DMSO |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Catharanthine is an alkaloid isolated from Madagascar periwinkle, inhibits voltage-operated L-type Ca2+ channel, with anti-cancer and blood pressure-lowering activity[1]. References:
[1]. Jadhav A, et al. Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes. J Pharmacol Exp Ther. 2013 Jun;345(3):383-92. |
