GS-704277是Remdesivir的丙氨酸代谢产物。Remdesivir是一种具有抗病毒活性的核苷类似物，在体外对SARS-CoV-2(COVID-19)感染具有很高的抑制作用。
| Cas No. | 1911579-04-8 |
| Canonical SMILES | N#C[C@@]1(C2=CC=C3N2N=CN=C3N)O[C@@H]([C@H]([C@H]1O)O)COP(N[C@@H](C)C(O)=O)(O)=O |
| 分子式 | C15H19N6O8P |
| 分子量 | 442.32 |
| 溶解度 | DMSO: soluble |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | GS-704277 is an alanine metabolite of Remdesivir. Remdesivir, a nucleoside analogue with effective antiviral activity, is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro[1][2]. [1]. Eastman RT, et al. Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19 [published correction appears in ACS Cent Sci. 2020 Jun 24;6(6):1009]. ACS Cent Sci. 2020;6(5):672-683.
[2]. Wang M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. |
