α-NETA 是一种有效且非竞争性的胆碱乙酰转移酶 (ChA; IC50\u003d76 μM) 和胆碱酯酶 (ChE; IC50\u003d40 μM) 抑制剂。 α-NETA 弱抑制乙酰胆碱酯酶 (AChE; IC50\u003d1 mM)。
| Cas No. | 31059-54-8 |
| 别名 | 2-(BETA-萘甲酰基)乙基三甲基碘化铵 |
| Canonical SMILES | O=C(CC[N+](C)(C)C)C1=CC2=CC=CC=C2C=C1.[I-] |
| 分子式 | C16H20NO•I |
| 分子量 | 369.2 |
| 溶解度 | DMSO: 3mg/ml,Methanol: Soluble |
| 储存条件 | Store at -20°C, protect from light, stored under nitrogen |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Choline acetyltransferase (ChAT) mediates the synthesis of the neurotransmitter acetylcholine from acetyl-CoA and choline. In addition to its critical role in neurosignaling, deficiencies in ChAT are linked to congenital myasthenic syndromes, Alzheimer's disease, and multiple sclerosis. α-NETA is a stable, non-competitive, and slowly reversible inhibitor of ChAT (IC50 = 9 μM). This naturally fluorescent compound is a poor inhibitor of cholinesterases and carnitine acetyltransferase. α-NETA is commonly used in cells in culture. |
