sPLA2 Inhibitor 是一种 D-酪氨酸衍生物，是一种口服有效的分泌型磷脂酶 A2 (sPLA2) 抑制剂，对人非胰腺分泌型 PLA2 异构体 IIa (hnpsPLA2-IIa) 的 IC50 为 29 nM。
| Cas No. | 393569-31-8 |
| Canonical SMILES | O=C(CCCCCCC1=CC=CC=C1)N[C@@H](CCC(O)=O)CC(C=C2)=CC=C2OCC3=CC=CC=C3 |
| 分子式 | C31H37NO4 |
| 分子量 | 487.6 |
| 溶解度 | DMF: 5 mg/ml,DMSO: 2 mg/ml,Ethanol: 5 mg/ml,Ethanol:PBS (pH 7.2) (1:6): 0.1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Secreted phospholipases A2 (sPLA2s) are a diverse family of low molecular weight PLA2s with tissue-specific expression patterns and actions. The group IIA sPLA2 (sPLA2-IIA) was originally purified from platelets and exudates from patients with rheumatoid arthritis. Its expression can be induced by inflammatory mediators, and mouse studies suggest that it may play roles in colorectal polyposis, atherosclerosis, and bacterial infections. sPLA2 inhibitor is an orally active inhibitor of sPLA2-IIA. It protects against intestinal reperfusion injury in rats when given at 10 mg/kg orally. sPLA2 inhibitor also attenuates NF-κB signaling in lung cancer cells and protects against diet-induced metabolic syndrome in rats. |
