EX-527 S-对映异构体 ((S)-EX-527) 是一种有效的选择性 SIRT1 抑制剂，IC50 为 98 nM。
| Cas No. | 848193-68-0 |
| 别名 | (1S)-6-氯-2,3,4,9-四氢-1H-咔唑-1-甲酰胺,(S)-EX-527 |
| 化学名 | (S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide |
| Canonical SMILES | ClC1=CC2=C(NC3=C2CCC[C@@H]3C(N)=O)C=C1 |
| 分子式 | C13H13ClN2O |
| 分子量 | 248.71 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Selisistat S-enantiomer (EX-527 S-enantiomer) is the S-enantiomer of Selisistat, with an IC50 of 123 nM for SIRT1. Selisistat S-enantiomer is much more potent than Selisistat R-enantiomer. References:
[1]. Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54. |
