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IOX 1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
IOX 1图片
CAS NO:5852-78-8
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)询价
10mg询价
50mg询价

IOX 1, 5-Carboxy-8-hydroxyquinoline 是一种有效的广谱 2OG 加氧酶抑制剂，包括 JmjC 脱甲基酶。 IOX 1 抑制 KDM4C、KDM4E、KDM2A、KDM3A 和 KDM6B，IC50 值分别为 0.6 μM、2.3 μM、1.8 μM、0.1 μM 和 1.4 μM。 IOX 1 也抑制 ALKBH5。
Cas No.5852-78-8
别名5-羰基-8-羟基喹啉
化学名8-hydroxyquinoline-5-carboxylic acid
Canonical SMILESOC1=C2N=CC=CC2=C(C(O)=O)C=C1
分子式C10H7NO3
分子量189.17
溶解度≥ 5.75mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IOX1, 5-Carboxy-8-hydroxyquinoline, is a potent broad‐spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. IOX1 inhibits KDM4C, KDM4E, KDM2A, KDM3A and KDM6B with IC50 values of 0.6 μM, 2.3 μM, 1.8 μM, 0.1 μM and 1.4 μM, respectively[1][2]. IOX1 also inhibits ALKBH5[3].

IOX1 (0-200 μM; 2 hours) inhibits the proliferation and migration of vascular smooth muscle cells (VSMCs) stimulated with angiotensin II (Ang II) in a concentration-dependent manner[2].IOX1 (200 μM; 24 hours) blocks the cell cycle progression of angiotensin II (Ang II)-VSMCs by increasing the percentage of cells in the G0/G1 phase[2].IOX1 (50-200 μM; 2 hours) attenuates cyclin D1 and upregulates p21 mRNA levels in a concentration-dependent[2].IOX1 (50-200 μM; 2 hours) mediates cyclin D1 and p21 expression by regaining H3K9me3[2].

References:
[1]. Schiller R, et al. A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. ChemMedChem. 2014 Mar;9(3):566-71.
[2]. Hu Q, et al. IOX1, a JMJD2A inhibitor, suppresses the proliferation and migration of vascular smooth muscle cells induced by angiotensin II by regulating the expression of cell cycle-related proteins. Int J Mol Med. 2016 Jan;37(1):189-96.
[3]. Li F, et al. A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5. Biomol Screen. 2016 Mar;21(3):290-7.

 
 
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