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CBB1007
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CBB1007图片
CAS NO:1379573-92-8
包装与价格：
包装价格(元)
5mg询价
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CBB1007 是一种细胞可渗透的脒基胍化合物，可作为一种有效的、可逆的和底物竞争性 LSD1 选择性抑制剂（hLSD1 的 IC50 = 5.27 μM）。
Cas No.1379573-92-8
化学名methyl 3-(4-(4-carbamimidoylbenzoyl)piperazine-1-carbonyl)-5-((4-carbamimidoylpiperazin-1-yl)methyl)benzoate
Canonical SMILESCOC(C1=CC(CN2CCN(C(N)=N)CC2)=CC(C(N3CCN(C(C4=CC=C(C(N)=N)C=C4)=O)CC3)=O)=C1)=O
分子式C27H34N8O4
分子量534.61
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CBB1007 is an inhibitor of histone demethylase LSD1with IC50 values of 5.27μM [1].

LSD1 is a member of the FAD-dependent amine oxidase family. It converts di-methylated H3K4 to mono- and un-methylated H3K4 and suppresses gene expression. As an inhibitor of LSD1, CBB1007 is developed to understand the function of the enzyme. In the in vitro assay, CBB1007 shows highly potent inhibitory activity with IC50 value of 5.27μM. It is specific against LSD1 and has no effect on other histone demethylases including LSD2 and JARID1A. In the mouse F9 embryonic teratocarcinoma cells, CBB1007 cause a reproducible increase of mono- and di-methylated H3K4 with IC50 value of 1μM-5μM. It also activates the expression of CHRM4 and SCN3A which are the target genes of LSD1. The inhibition of LSD1 results in the growth inhibition of these cells. Furthermore, CBB1007 is found to inhibit the proliferation of other pluripotent cancer cells as well as the embryonic stem cells that express the stem cell markers Oct4 and Sox2 [1].

References:
[1] Wang J, Lu F, Ren Q, et al. Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties. Cancer research, 2011, 71(23): 7238-7249.

 
 
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