IM-93 抑制 ferroptosis 和 NETosis，抑制细胞死亡的 IC50 为 0.45 μM 。
| Cas No. | 1173657-73-2 |
| Canonical SMILES | O=C(C(C1=CN(C)C2=C1C=CC=C2)=C3NCCCN(C)C)N(C(C)C)C3=O |
| 分子式 | C21H28N4O2 |
| 分子量 | 368.5 |
| 溶解度 | DMF: 20mg/mL,DMSO: 20mg/mL,DMSO:PBS (pH 7.2) (1:2): 0.3mg/mL,Ethanol: 1mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | IM-93 is a dual inhibitor of ferroptosis and NETosis.1 It inhibits tert-butyl hydroperoxide- and erastin-induced ferroptosis in NIH3T3 cells (IC50s =1.8 and 1.9 nM, respectively), as well as decreases NETosis induced by phorbol 12-myristate 13-acetate in isolated human peripheral blood neutrophils when used at concentrations ranging from 1.6 to 25 μM. IM-93 also inhibits hydrogen peroxide-induced necrosis in HL-60 cells (IC50 = 0.45 μM), but has no effect on necroptosis induced by Fas ligand in combination with Z-VAD-FMK and cycloheximide in Jurkat cells or pyroptosis induced by S. aureus and P. aeruginosa in THP-1 cells when used at a concentration of 25 μM. |1. Dodo, K., Kuboki, E., Shimizu, T., et al. Development of a water-soluble indolylmaleimide derivative IM-93 showing dual inhibition of ferroptosis and NETosis. ACS Med. Chem. Lett. 10(9), 1272-1278 (2019). |
