| CAS NO: | 612530-44-6 |
| Cas No. | 612530-44-6 |
| 别名 | 5-苯基-1,2,5-噻二唑烷-3-酮1,1-二氧化物,PTP1B inhibitor |
| Canonical SMILES | O=S(N1C2=CC=CC=C2)(NC(C1)=O)=O |
| 分子式 | C8H8N2O3S |
| 分子量 | 212.23 |
| 溶解度 | DMSO: ≥ 38 mg/mL (179.05 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | PTP1B-IN-1 is a potent protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 1.6 mM; 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for derivatives synthesis. [1]. Black E, et al. Structure-based design of protein tyrosine phosphatase-1B inhibitors. Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7. [2]. Vintonyak VV, et al. Using small molecules to target protein phosphatases. Bioorg Med Chem. 2011 Apr 1;19(7):2145-55. |
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