DB2115 (tertahydrochloride) 是一种有效的骨髓主调节剂 PU.1 抑制剂。 DB2115 (tertahydrochloride) 具有研究癌症的潜力，包括白血病等血液系统癌症以及与 PU 相关的其他疾病。 1 功能障碍（摘自专利WO2017223260A1，化合物DB2115）。
| Cas No. | 368449-04-1 |
| 别名 | Telomerase Inhibitor IX |
| 化学名 | N,N'-1,3-phenylenebis[2,3-dihydroxy-benzamide |
| Canonical SMILES | OC1=C(O)C(C(NC2=CC=CC(NC(C3=C(O)C(O)=CC=C3)=O)=C2)=O)=CC=C1 |
| 分子式 | C20H16N2O6 |
| 分子量 | 380.4 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:40): 0.025 mg/ml,Ethanol: 0.2 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | MST312 is a telomerase inhibitor (IC50 = 0.67 μM in a TRAP assay). It is selective for telomerase over DNA polymerase when used at concentrations up to 3 μM. MST312 inhibits growth of U937 cells via telomere shortening (GI50 = 1.7 μM). It reduces cell number and expression of the proliferation marker MIB-1 as well as increases DNA damage in primary pediatric ependymoma tumor cells. MST312 decreases survival of H460 and H1299 non-small cell lung cancer (NSCLC) cells in a dose-dependent manner with a greater effect on the aldehyde dehydrogenase positive (ALDH+) cancer stem cell population. In vivo, MST312 (40 mg/kg) reduces tumor size by 70% in an H460 mouse xenograft model. MST312 also inhibits replication of herpes simplex virus 2 (HSV-2) and a clinical isolate of HSV-1 and decreases accumulation of early and late viral proteins in HEp-2 cells infected with HSV-1. |
