G907 是 ABC transporter, MsbA 的选择性小分子拮抗剂。 G907 抑制两栖动物中纯化的大肠杆菌 MsbA (IC50=18 nM)。G907 通过楔入结构上保守的跨膜袋，使 MsbA 陷入向内的脂多糖结合构象中。G907 具有杀菌活性。
| Cas No. | 2244035-16-1 |
| Canonical SMILES | O=C(O)/C=C/C1=C(C2CC2)C3=CC(OC(C4=C(C5CC5)C=CC=C4Cl)C)=CC=C3N=C1 |
| 分子式 | C26H24ClNO3 |
| 分子量 | 433.93 |
| 溶解度 | DMSO: 83.33 mg/mL (192.04 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | G907 is a selective small-molecule antagonist of ATP-binding cassette (ABC) transporter, MsbA. It inhibits purified E. coli MsbA in amphipols with an IC50 of 18 nM. G907 traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket. Bactericidal activity[1]. [1]. Ho H, et al. Structural basis for dual-mode inhibition of the ABC transporter MsbA. Nature. 2018 May;557(7704):196-201. |
