Desmethyl ferroquine (SSR97213) 是 Ferroquine 的主要活性代谢产物。Ferroquine 是一种抗疟剂。Desmethyl ferroquine 显著抑制对 Chloroquine 敏感的和耐 Chloroquine 的恶性疟原虫菌株 P. falciparum。
| Cas No. | 903546-18-9 |
| 别名 | SSR97213 |
| Canonical SMILES | CNCC12=[CH]3[Fe+2]1456789([CH-]%10[CH]6=[CH]7[CH]8=[CH]9%10)[C-]2([CH]4=[CH]53)CNC%11=CC=NC%12=C%11C=CC(Cl)=C%12 |
| 分子式 | C22H22ClFeN3 |
| 分子量 | 419.73 |
| 溶解度 | DMSO: 2.5 mg/mL (5.96 mM); Water:< 0.1 mg/mL (insoluble) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Desmethyl ferroquine (SSR97213) is the active and major metabolite of Ferroquine. Ferroquine is an antimalarial. Desmethyl ferroquine shows significant activity against Chloroquine-susceptible and resistant P. falciparum strains[1]. [1]. Supan C, et al. Pharmacokinetics of ferroquine, a novel 4-aminoquinoline, in asymptomatic carriers of Plasmodium falciparum infections. Antimicrob Agents Chemother. 2012 Jun;56(6):3165-73. |
