An antifungal lipopeptide
| Cas No. | 144371-88-0 |
| Canonical SMILES | O=C(N[C@]([C@H](O)CC(N)=O)([H])C(N1[C@@](C(N[C@H](O)[C@H](O)C[C@@H]2NC(CCCCCCCCCCCCCCC)=O)=O)([H])[C@@H](O)[C@@H](C)C1)=O)[C@@]([C@H](O)[C@@H](O)C3=CC=C(O)C(OS(O)(=O)=O)=C3)([H])NC([C@@]4([H])N(C([C@@]([C@H](O)C)([H])NC2=O)=O)C[C@H](O)C4)=O |
| 分子式 | C51H82N8O21S |
| 分子量 | 1175.3 |
| 溶解度 | Methanol: slightly soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | FR901379 is an echinocandin-like antifungal lipopeptide.1 It is active against C. albicans, C. krusei, C. tropicalis, C. utilis, A. fumigatus, and A. niger fungi (IC50s = <0.003-1.9 μg/ml). FR901379 is protective against C. albicans infection in mice (ED50 = 1.1 mg/kg). It also reduces the number of pulmonary cysts and trophozoites in a mouse model of P. carinii infection. |1. Fujie, A., Iwamoto, T., Sato, B., et al. FR131535, a novel water-soluble echinocandin-like lipopeptide: Synthesis and biological properties. Bioorg. Med. Chem. Lett. 11(3), 399-402 (2001). |
