决奈达隆 (SR 33589) 是胺碘酮的衍生物，是一种 III 类抗心律失常药物，用于研究心房颤动 (AF) 和心房扑动。
| Cas No. | 141626-36-0 |
| 别名 | 决奈达隆; SR 33589 |
| 化学名 | N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide |
| Canonical SMILES | CCCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C)C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC |
| 分子式 | C31H44N2O5S |
| 分子量 | 556.77 |
| 溶解度 | ≥ 27.8 mg/mL in DMSO, ≥ 49.8 mg/mL in EtOH |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Dronedarone (SR 33589) is a newer therapeutic agent with a structural resemblance to amiodarone and a better side effect profile; it is a multichannel blocker with antiadrenergic properties and has been evaluated in both rate and rhythm control strategies in the management of AF. References:
[1]. Piccinni C, et al.Trends in antiarrhythmic drug use after marketing authorization of dronedarone: comparison between Emilia Romagna (Italy) and Sweden.Eur J Clin Pharmacol. 2012 Sep 1.
[2]. Benaim G, et al.The emerging role of amiodarone and dronedarone in Chagas disease.Nat Rev Cardiol. 2012 Aug 7.
[3]. Rosman J, et al. Possible Proarrhythmia with Dronedarone.J Cardiovasc Electrophysiol. 2012 Jul 19.
[4]. Kao DP, et al. Proarrhythmic Potential of Dronedarone: Emerging Evidence from Spontaneous Adverse Event Reporting.Pharmacotherapy. 2012 Jun 28.
[5]. Manakshe G, Rao BH.Dronedarone-current status in management of atrial fibrillation.Indian Heart J. 2012 Mar-Apr;64(2):182-6. Epub 2012 Apr 28. |
