| CAS NO: | 58-49-1 |
| 包装 | 价格(元) |
| 10mM (in 1mL Water) | 询价 |
| 5mg | 询价 |
| 50mg | 询价 |
| 100mg | 询价 |
Angiotensin II 5-valine 是血管紧张素受体 (angiotensin receptor) 的激动剂。
| Cas No. | 58-49-1 |
| 别名 | 血管紧张素 Ⅱ 5-缬氨酸; Valine angiotensin II; 5-L-Valine angiotensin II |
| 分子式 | C49H69N13O12 |
| 分子量 | 1032.15 |
| 溶解度 | Water : ≥ 257.5 mg/mL (249.48 mM) |
| 储存条件 | -20°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Angiotensin II 5-valine is an agonist of angiotensin receptor. Angiotensin receptor[1]. By day 12, systolic blood pressure (SBP) increases significantly in Angiotensin II 5-valine infused rats (197±7 mm Hg). As shown, the development of hypertension in ANG II infused rats is prevented by losartan treatment. Blood and kidney samples are harvested, subjected to HPLC to separate Angiotensin II 5-valine (exogenous) from Ile5-ANG II (endogenous) and the fractions are measured by radioimmunoassay. In the Angiotensin II 5-valine infused rats treated with losartan, total plasma ANG II levels are elevated to a greater extent than in rats not treated with losartan (289±20 v 119±14 fmol/mL). However, losartan markedly decrease by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone[1]. [1]. Zou LX et al. Renal uptake of circulating angiotensin II in Val5-angiotensin II infused rats is mediated by AT1 receptor. Am J Hypertens. 1998 May;11(5):570-8. |
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