5-O-Demethylnobiletin

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CAS NO:

2174-59-6

5-O-Demethylnobiletin (5-Demethylnobiletin) 5-O-去甲肾上腺素，一种从黄芪中分离出的多甲氧基黄酮，是 5-LOX 的直接抑制剂 (IC50=0.1 μM)，不影响 COX-2 的表达。5-O-Demethylnobiletin (5-Demethylnobiletin) 5-O-去甲肾上腺素具有抗炎活性，抑制大鼠中性粒细胞中白三烯 B (4)(LTB4) 的形成和人嗜中性粒细胞中弹性蛋白酶的释放，IC50 值为0.35 μM.5-O-Demethylnobiletin (5-Demethylnobiletin) 5-O-去甲肾上腺素通过激活 MAPK/ERK-，PKC- 和 PKA 依赖性信号传导途径促进神经发生。

Cas No.	2174-59-6
别名	去甲基川陈皮素,5-Demethylnobiletin
Canonical SMILES	O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=C(OC)C(OC)=C(OC)C(O)=C13
分子式	C₂₀H₂₀O₈
分子量	388.37
溶解度	Soluble in DMSO
储存条件	4°C, protect from light
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Sideritis tragoriganum, is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM[1].5-O-Demethylnobiletin (5-demethylnobiletin) promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent signaling pathways[2]. IC50: 0.1 μM (Lox 5); 0.35 μM (LTB4) (5-O-Demethylnobiletin)[1] [1]. Bas E, et al. Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganum. Planta Med. 2006 Feb;72(2):136-42. [2]. Chiu SP, et al. Neurotrophic action of 5-hydroxylated polymethoxyflavones: 5-demethylnobiletin and gardenin A stimulate neuritogenesis in PC12 cells. J Agric Food Chem. 2013 Oct 2;61(39):9453-63.