ML-184 (CID2440433) 是一种选择性 GPR55 激动剂，EC50 为 250 nM，对 GPR55 的选择性比 GPR35、CB1 和 CB2 高 100 倍以上。
| Cas No. | 794572-10-4 |
| 别名 | CID2440433 |
| Canonical SMILES | CC1=CC=CC(N2CCN(C(C3=CC(S(N(C)C)(=O)=O)=CC=C3N4CCCC4)=O)CC2)=C1C |
| 分子式 | C25H34N4O3S |
| 分子量 | 470.6 |
| 溶解度 | DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml,DMSO: 20 mg/ml,Ethanol: 1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | GPR55 is a G protein-coupled receptor that is weakly activated by some cannabinoids (CBs) at nM concentrations but displays a 5- to 10-fold greater stimulation in response to 1 µM lysophosphatidylinositol (LPI). ML-184 is a potent synthetic agonist of GPR55 (EC50 = 0.26 µM). It does not act at the related kynurenic acid receptor GPR35 and is a weak antagonist of CB1 and CB2 (IC50s = 21.8 and 15.1 µM, respectively). Like LPI, ML-184 induces phosphorylation of ERK1/2 and translocation of PKCβII to the plasma membrane by activating GPR55. |
