Linearmycin A is a polyene antibiotic that has been found inStreptomyces.¹It is active against the bacteriaS. aureusandE. coli(MICs = 3.1 and 1.6 µg/disc, respectively), the fungiS. cerevisiaeandC. albicans(MICs = 0.1 and 1.6 µg/disc, respectively), and the plant pathogenic fungusA. nigerin disc assays (MIC = 0.2 µg/disc). Linearmycin A induces lysis and degradation ofB. subtilisas a component ofStreptomycesMg1 extract.²

1.Sakuda, S., Guce-Bigol, U., Itoh, M., et al.Novel linear polyene antibiotics: LinearmycinsJ. Chem. Soc., Perkin Trans. 1182315-2319(1996) 2.Stubbendieck, R.M., and Straight, P.D.Escape from lethal bacterial competition through coupled activation of antibiotic resistance and a mobilized subpopulationPLoS Genet.11(12)e1005722(2015)