STING Agonist 1a (1a) 是干扰素基因 (STING) 激动剂的特异性刺激剂。
| Cas No. | 652142-94-4 |
| Canonical SMILES | ClC1=NC2=C(N3C1=NN=C3C4=C(Cl)N=C5C=CC(OC)=CC5=C4)C=CC=C2 |
| 分子式 | C19H11Cl2N5O |
| 分子量 | 396.2 |
| 溶解度 | DMF: slightly soluble,DMSO: slightly soluble,PBS (pH 7.2): slightly soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 µM). STING agonist 1a (12.5-100 µM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 . 1.Hou, H., Yang, R., Liu, X., et al.Discovery of triazoloquinoxaline as novel STING agonists via structure-based virtual screeningBioorg. Chem.100103958(2020) |
