姜黄素 ((-)-Curcumol) 是一种具有生物活性的倍半萜类化合物，具有多种药理活性，如抗癌、抗菌、抗真菌、抗病毒和抗炎。姜黄醇通过靶向关键信号通路如 MAPK/ERK、PI3K/Akt 和 NF-κB，在许多癌细胞中是一种有效的细胞凋亡诱导剂，这些信号通路通常在几种癌症中失调。
| Cas No. | 4871-97-0 |
| 别名 | 姜黄醇; (-)-Curcumol |
| 化学名 | (3S,5S,6S,8aS)-5-isopropyl-3-methyl-8-methyleneoctahydro-1H-3a,6-epoxyazulen-6-ol |
| Canonical SMILES | [H][C@]12C(C([H])([H])[C@@]3([H])C(C([H])([H])[H])([H])C([H])([H])[H])([C@](C([H])([H])[H])([H])C([H])([H])C1([H])[H])O[C@]3(C([H])([H])/C2=C([H])\[H])O[H] |
| 分子式 | C15H24O2 |
| 分子量 | 236.35 |
| 溶解度 | ≥ 9.4mg/mL in DMSO |
| 储存条件 | Store at 4°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Curcumol is a sesquiterpene originally isolated from curcuma rhizomes; shows anticancer activities both in vitro and in vivo.IC50 value:Target: Anticancer natural compoundin vitro: Curcumol exhibited time- and concentration-dependent anti-proliferative effects in SPC-A-1 human lung adenocarcinoma cells with cell cycle arrest in the G0/G1 phase while apoptosis-induction was also confirmed with flow cytometry and morphological analyses [1]. Curcumol-induced growth inhibition correlated with apoptosis induction as evidenced by Annexin V staining, and cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP) in HSC-T6. Suppression of the NF-κB translocation via inhibition of IκB-α phosphorylation by the curcumol led to the inhibition of expression of NF-κB-regulated gene, e.g. Bcl-xL and Bcl-2, in a PI3K-dependent manner, which is upstream of NF-κB activation [2]. Curcumol exhibits an inhibitory effect on receptor activator of nuclear factor kappaB ligand (RANKL)-induced osteoclast differentiation with both bone marrow-derived macrophages and RAW264.7 cells in a dose-dependent manner [3].in vivo: Anti-neoplastic effects of curcumol were also confirmed in tumor bearing mice. Curcumol (60 mg/kg daily) significantly reduced tumor size without causing notable toxicity [1]. References:
[1]. Tang QL, et al. Curcumol induces apoptosis in SPC-A-1 human lung adenocarcinoma cells and displays anti-neoplastic effects in tumor bearing mice. Asian Pac J Cancer Prev. 2015;16(6):2307-12.
[2]. Chen G, et al. Curcumol induces HSC-T6 cell death through suppression of Bcl-2: involvement of PI3K and NF-κB pathways. Eur J Pharm Sci. 2014 Dec 18;65:21-8.
[3]. Yu M, et al. Curcumol suppresses RANKL-induced osteoclast formation by attenuating the JNK signaling pathway. Biochem Biophys Res Commun. 2014 May 2;447(2):364-70. |
