| CAS NO: | 869298-22-6 |
| 包装 | 价格(元) |
| 5mg | 询价 |
| 25mg | 询价 |
| Cas No. | 869298-22-6 |
| Canonical SMILES | COC1=CC=CC(CNC(C2=NC(C3=C(SC=C3COCC4=CC=C(C(O[Na])=O)C=C4)N2[Na])=O)=O)=C1 |
| 分子式 | C24H19N3Na2O6S |
| 分子量 | 523.47 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Highly potent and selective MMP13 inhibitor (IC50 = 6.9 pM). Exhibits >2600-fold selectivity for MMP13 over related MMPs. Inhibits degradation of bovine nasal septum cartilage explants in vitro . Orally bioavailable. Nara et al (2014) Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1" binding site. Bioorg.Med.Chem. 22 5487 PMID:25192810 |
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