Chaetoglobosin A 是青霉提取物中的活性成分，是细胞松弛素家族的成员。
| Cas No. | 50335-03-0 |
| 别名 | 球毛壳菌素 A |
| Canonical SMILES | C/C([C@@H](O)C(/C=C/C1=O)=O)=C/[C@@H](C)C/C=C/[C@]2([H])[C@]1(C(N[C@H]3CC4=CNC5=C4C=CC=C5)=O)[C@@]3([H])[C@H](C)[C@]6(C)[C@H]2O6 |
| 分子式 | C32H36N2O5 |
| 分子量 | 528.6 |
| 溶解度 | Methanol: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Chaetoglobosin A, the active principle within the extract of Penicillium aquamarinium, is a member of the cytochalasan family. Chaetoglobosin A preferentially induces apoptosis. Chaetoglobosin A targets filamentous actin in CLL cells and thereby induces cell-cycle arrest and inhibits membrane ruffling and cell migration[1]. References:
[1]. Knudsen PB, et al. Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. Leukemia. 2014 Jun;28(6):1289-98. |
