CAY10575 (Compound 8) 是一种 IKK2 抑制剂，IC50 为 0.075 μM。
| Cas No. | 916985-21-2 |
| Canonical SMILES | COc1cc2c(ncn2c2cc(OCc3ccc(cc3)S(=O)(=O)C)c(s2)C(=O)N)cc1OC |
| 分子式 | C22H21N3O6S2 |
| 分子量 | 487.6 |
| 溶解度 | DMF: 1mg/mL,DMSO: 10mg/mL,DMSO:PBS(7.2pH) 1:4: 0.2mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | The NF-κB/Rel transcription factors, known to be involved in the regulation of pro-inflammatory cytokines and the pathogenesis of a variety of diseases, are present in the cytosol in an inactive state, complexed with inhibitory IκB proteins. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. IKK-ε, a homolog of IKK-α and IKK-β, can also activate NF-κB. IKK-ε is expressed predominantly in immune cells and is thought to play a role in the immune response. CAY10575 is a benzimidazole analog that inhibits IKK-ε with an IC50 value of ~15.8 µM. |
