Thiolutin (Acetopyrrothin) 是一种由链霉菌产生的含二硫化物的抗生素和抗血管生成化合物。
| Cas No. | 87-11-6 |
| 别名 | 硫藤黄素,Acetopyrrothin |
| 化学名 | N-(4-methyl-5-oxodithiolo[4,3-b]pyrrol-6-yl)acetamide |
| Canonical SMILES | CC(=O)NC1=C2C(=CSS2)N(C1=O)C |
| 分子式 | C8H8N2O2S2 |
| 分子量 | 228.28 |
| 溶解度 | DMF: 0.5 mg/ml,DMSO: 1 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml |
| 储存条件 | Desiccate at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Thiolutin (Acetopyrrothin) is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Thiolutin inhibits the JAMM metalloproteases Csn5, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH) and Brcc36[1]. Thiolutin is a potent and selective inhibitor of endothelial cell adhesion accompanied by rapid induction of Heat-shock protein beta-1 (Hsp27) phosphorylation[2]. References:
[1]. Lauinger L, et al. Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases. Nat Chem Biol. 2017 Jul;13(7):709-714.
[2]. Jia Y, et al. Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton. Cell Stress Chaperones. 2010 Mar;15(2):165-81. |
