DR 2313 是一种强效、选择性、竞争性和脑渗透性聚（ADP-核糖）聚合酶 (PARP) 抑制剂，对 PARP-1 和 PARP-2 的 IC50 分别为 0.20 μM 和 0.24 μM。
| Cas No. | 284028-90-6 |
| 别名 | 3,5,7,8-四氢-2-甲基-4H-硫代吡喃并[4,3-D]嘧啶-4-酮 |
| 化学名 | 2-methyl-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one |
| Canonical SMILES | CC1=NC(=O)C2=C(N1)CCSC2 |
| 分子式 | C8H10N2OS |
| 分子量 | 182.24 |
| 溶解度 | ≥ 83.3mg/mL in DMSO, ≥ 9.1mg/mL in Water |
| 储存条件 | Store at 4℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Competitive inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50values are 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). Neuroprotective; reduces neuronal cell death in models of cerebral ischemiain vivoandin vitro. Brain penetrant. |
