| CAS NO: | 1340593-59-0 |
| Cas No. | 1340593-59-0 |
| 别名 | VT-1161 |
| Canonical SMILES | O[C@@](CN1C=NN=N1)(C(C=CC(F)=C2)=C2F)C(F)(C3=CC=C(C4=CC=C(OCC(F)(F)F)C=C4)C=N3)F |
| 分子式 | C23H16F7N5O2 |
| 分子量 | 527.39 |
| 溶解度 | DMSO: ≥ 270 mg/mL (511.96 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Oteseconazole (VT-1161) is an orally active anti-fungal agent, potently binds to and inhibits Candida albicans CYP51 (Kd,<39 nM), shows no obvious effect on human CYP51[1][2]. [1]. Warrilow AG, et al. The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme. Antimicrob Agents Chemother. 2014 Dec;58(12):7121-7. [2]. Garvey EP, et al. VT-1161 dosed once daily or once weekly exhibits potent efficacy in treatment of dermatophytosis in a guinea pig model. Antimicrob Agents Chemother. 2015 Apr;59(4):1992-7. |
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