| CAS NO: | 921605-87-0 |
| Cas No. | 921605-87-0 |
| Canonical SMILES | FC(C1=CC=CC=C1OC2CCN(C3=NN=C(C4=NN=C(C)S4)C=C3)CC2)(F)F |
| 分子式 | C19H18F3N5OS |
| 分子量 | 421.44 |
| 溶解度 | DMSO: 62.5 mg/mL (148.30 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an EC50 of 2.3 nM for rSCD1[1]. EC50: 2.3 nM (rSCD1)[1] MF-438 exhibits an ED50 between 1 and 3 mg/kg in a mouse model[1]. [1]. LÉger S, et al. Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438). Bioorg Med Chem Lett. 2010 Jan 15;20(2):499-502. |
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