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CYP17-IN-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CYP17-IN-1图片
CAS NO:2093317-51-0

CYP17-IN-1 (compound 9c) 是一种有效的，具有口服活性的 CYP17 的抑制剂，对大鼠和人 CYP17 的 IC50 值为 15.8 和 20.1 nM。
Cas No.2093317-51-0
Canonical SMILESCC1=CC=NC=C1CN(CC2)CC3=C2C4=CC(F)=CC=C4S3
分子式C18H17FN2S
分子量312.4
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM[1]. IC50: 15.8 nM (Rat CYP17), 20.1 nM (Human CYP17)[1]

CYP17-IN-1 (compound 9c) exhibits an IC50 value of 8.5 µM against CYP3A4[1].

CYP17-IN-1 (compound 9c) reduces plasma testosterone level in a dose-dependent manner in Sprague-Dawley rats[1].

[1]. Wang M, et al. Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors. Eur J Med Chem. 2017 May 26;132:157-172.

 
 
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