tetranor-PGEM 是前列腺素 E2 (PEG2) 的代谢物，是炎症和癌症的生物标志物，包括晚期结直肠肿瘤、卵巢癌、前列腺癌等。
| Cas No. | 24769-56-0 |
| 别名 | tetranor-Prostaglandin E Metabolite |
| 化学名 | 9,15-dioxo-11α-hydroxy-13,14-dihydro-2,3,4,5-tetranor-prostan-1,20-dioic acid |
| Canonical SMILES | O[C@H]1[C@H](CCC(CCCCC(O)=O)=O)[C@@H](CCC(O)=O)C(C1)=O |
| 分子式 | C16H24O7 |
| 分子量 | 328.4 |
| 溶解度 | 50mg/mL in DMSO, or in DMF |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | tetranor-PGEM is the major urinary metabolite of PGE1 and PGE2, and is used as a marker of PGE2 biosynthesis.[1],[2] About 15% of an infused dose of PGE2 appears as this metabolite in the urine of humans. Normal healthy males excrete 7-40 μg of tetranor-PGEM over a 24-hour period.[1] Reference:
[1]. Hamberg, M. Inhibition of prostaglandin synthesis in man. Biochemical and Biophysical Research Communications 49, 720-726 (1972).
[2]. Honda, H., Fukawa, K., and Sawabe, T. Influence of adjuvant arthritis on main urinary metabolites of prostaglandin F and E rats. Prostaglandins 19, 259-269 (1980). |
