4-hydroperoxy Cyclophosphamide

首页蛋白库基因库产品会员服务

位置：首页 > 产品库 > 4-hydroperoxy Cyclophosphamide

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

39800-16-3

包装与价格：

包装	价格(元)
1mg	询价
5mg	询价
10mg	询价
25mg	询价

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	293.08
Cas No.	39800-16-3
Formula	C₇H₁₅Cl₂N₂O₄P
Solubility	Soluble in chloroform
Chemical Name	2-(bis(2-chloroethyl)amino)-4-hydroperoxy-1,3,2-oxazaphosphinane 2-oxide
Canonical SMILES	O=P1(N(CCCl)CCCl)OCCC(OO)N1
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

4-hydroperoxy Cyclophosphamide is the active metabolite form of the prodrug Cyclophosphamide. It crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS)[1]. Formulations containing the prodrug Cyclophosphamide are used to treat lymphomas and autoimmune disorders[2,3].

References:

[1]. Strauss G, Westhoff M A, Fischer-Posovszky P, et al. 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. Cell Death Differ, 2008, 15(2): 332-343.

[2]. Ahmed A R, Hombal S M. Cyclophosphamide (Cytoxan). A review on relevant pharmacology and clinical uses. J. Am. Acad. Dermatol, 1984, 11(6): 1115-1126.

[3]. Appel G B. New and future therapies for lupus nephritis. Cleve. Clin. J. Med, 2012, 79(2): 134-140.