Zinquin ethyl ester

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Zinquin ethyl ester

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

181530-09-6

包装与价格：

包装	价格(元)
500ug	询价
1mg	询价
5mg	询价
10mg	询价

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	414.47
Cas No.	181530-09-6
Formula	C₂₁H₂₂N₂O₅S
Solubility	≤0.5mg/ml in ethanol;25mg/ml in DMSO;30mg/ml in dimethyl formamide
Chemical Name	ethyl 2-((2-methyl-8-(4-methylphenylsulfonamido)quinolin-6-yl)oxy)acetate
Canonical SMILES	CC1=CC=C(S(NC2=C(N=C(C)C=C3)C3=CC(OCC(OCC)=O)=C2)(=O)=O)C=C1
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Zinquin ethyl ester, a cell-permeable, quinolone-based fluorescent probe, is commonly used as a zinc indicator [1].

Zinc is an important component of many enzymes, transcription factors, and other functional proteins, where it exerts specific actions over a wide range of physiological processes, such as growth, development, and functioning of the endocrine, immune, and nervous systems, and may contribute to the development of tumors [2].

In pig kidney LLC-PK1 cells treated with diethylamine NONOate (DEA-NO), 20 μM zinquin ethyl ester was used for detection of Zn²⁺ release [1]. In normal human prostate epithelial (NHPrE) cells, 25 μM zinquin ethyl ester was used to quantify the free labile zinc level, emitting four times stronger fluorescence than zinquin [2]. In wild-type murine aortic endothelial cells, zinquin ethyl ester at the concentration of 25 μM, was employed to track intranuclear Zn²⁺ release, triggered by NO which was derived from the inducible NO synthase activity [3].

References:

[1]. Karim M R, Petering D H. Detection of Zn²⁺ release in nitric oxide treated cells and proteome: dependence on fluorescent sensor and proteomic sulfhydryl groups. Metallomics, 2017, 9(4): 391-401.

[2]. Zhang J J, Wu M, Schoene N W, et al. Effect of resveratrol and zinc on intracellular zinc status in normal human prostate epithelial cells. American Journal of Physiology-Cell Physiology, 2009, 297(3): C632-C644.

[3]. Spahl D U, Berendji-Grün D, Suschek C V, et al. Regulation of zinc homeostasis by inducible NO synthase-derived NO: nuclear metallothionein translocation and intranuclear Zn²⁺ release. Proceedings of the National Academy of Sciences of the United States of America, 2003, 100(24): 13952-13957.