TOFA

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TOFA

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CAS NO:

54857-86-2

包装与价格：

包装	价格(元)
5mg	询价
10mg	询价
50mg	询价
100mg	询价

化学性质

Storage	Store at -20°C
M.Wt	324.45
Cas No.	54857-86-2
Formula	C₁₉H₃₂O₄
Solubility	insoluble in H2O; ≥2.05 mg/mL in EtOH with ultrasonic; ≥32.4 mg/mL in DMSO with ultrasonic
Chemical Name	5-(tetradecyloxy)furan-2-carboxylic acid
Canonical SMILES	CCCCCCCCCCCCCCOC1=CC=C(O1)C(O)=O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

TOFA (5-tetradecyloxy-2-furoic acid) is an endogenous small molecule, as an allosteric agent, which targets Acetyl-CoA carboxylase (ACC) [1].

ACC is a rate-limiting enzyme in fatty acid metabolism, which catalyzes the carboxylation of Acetyl-CoA to malonyl-CoA in an ATP-dependent way.

Inhibition of acetyl-CoA carboxylase-α (ACCA) treated by TOFA decreased fatty acid synthesis and induced caspase activation and cell death in most PCa cell lines. Besides, TOFA induced cell apoptosis via the mitochondrial pathway in androgen-sensitive cell lines by inducing the release of cytochromec from mitochondria [2].

Rats were fed diets containing varying concentrations of TOFA or clofibrate for 4-10 days. Compared with untreated control rats, TOFA produced a dose-dependent reduction of plasma cholesterol levels, which achieved a higher reduction at 583μmol/kg/day than 40% reduction treated by clofibrate in a dose range of 766-1693μmol/kg/day [1].

Reference:

[1] Parker R A, Kariya T, Grisar J M. Petrow V. 5-(Tetradecyloxy)-2-furancarboxylic acid and related hypolipidemic fatty acid-like alkyloxyarylcarboxylic acids [J]. J Med Chem. 1977, 20(6): 781–791.

[2] Guseva N V, Rokhin O W, Glover R A, et al. TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status [J]. Cancer Biol Ther. 2011, 12(1): 80-85.