2-chloro-3-Deazaadenosine

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CAS NO:

40656-71-1

包装与价格：

包装	价格(元)
1mg	询价
5mg	询价
10mg	询价

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	300.7
Cas No.	40656-71-1
Formula	C₁₁H₁₃ClN₄O₄
Synonyms	6-Amino-2-chloropurine riboside,2-CADO,NSC 158900
Solubility	≤0.25mg/ml in ethanol;2mg/ml in DMSO;2mg/ml in dimethyl formamide
Chemical Name	6-chloro-1-β-D-ribofuranosyl-1H-imidazo[4,5-c]pyridin-4-amine
Canonical SMILES	O[C@H]1[C@H](N2C=NC3=C2C=C(Cl)N=C3N)O[C@H](CO)[C@H]1O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

2-chloro-3-Deazaadenosine, a stable analog of adenosine, is an agonist for adenosine receptors [1].

Adenosine receptors are members of G-protein-coupled receptors (GPCRs). Extracellular adenosine acts as a local modulator with a generally cytoprotective function in the body. Extracellular adenosine has been implicated in increasing the ratio of oxygen supply to demand, protecting against ischaemic damage by cell conditioning, triggering anti-inflammatory responses and the promotion of angiogenesis [2].

In vitro: The Ki values of 2-chloro-3-Deazaadenosine for A1, A2A, A2B, and A3 receptors were 0.3, 0.08, 25.5, and 1.9 μM, respectively [1]. 2-chloroadenosine (25 μM) increased activity of platelet adenylate cyclase to about 150–160% of the control value. Higher concentrations of 2-chloroadenosine showed less effect above 100 μM [3].

In vivo: In the rat with delayed ischaemic damage, Iterative focal injections of 2-chloroadenosine protected against selective hippocampal CA1 loss [4].

References:
[1] Linden J, Thai T, Figler H, et al. Characterization of Human A2B Adenosine Receptors: Radioligand Binding, Western Blotting, and Coupling to Gqin Human Embryonic Kidney 293 Cells and HMC-1 Mast Cells[J]. Molecular Pharmacology, 1999, 56(4): 705-713.
[2] Jacobson K A, Gao Z G. Adenosine receptors as therapeutic targets[J]. Nature Reviews Drug Discovery, 2006, 5(3): 247-264.
[3] Haslam R J, Lynham J A. Activation and inhibition of blood platelet adenylate cyclase by adenosine or by 2-chloroadenosine[J]. Life Sciences, 1972, 11(23): 1143-1154.
[4] Evans M C, Swan J H, Meldrum B S. An adenosine analogue, 2-chloroadenosine, protects against long term development of ischaemic cell loss in the rat hippocampus[J]. Neuroscience letters, 1987, 83(3): 287-292.