| CAS NO: | 71963-77-4 |
Semi-synthetic derivative of artemisinin
| Cas No. | 71963-77-4 |
| 别名 | 蒿甲醚; Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224 |
| 化学名 | (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene |
| Canonical SMILES | [H][C@]12[C@@]3([C@@]4([H])CC[C@@]2([H])C)[C@@](O[C@H](OC)[C@@]4(C)[H])([H])O[C@@](OO3)(C)CC1 |
| 分子式 | C16H26O5 |
| 分子量 | 298.4 |
| 溶解度 | ≥ 15.3 mg/mL in DMSO, ≥ 90.2 mg/mL in EtOH |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Artemether is a semi-synthetic derivative of artemisinin (qinghaosu), a naturally occurring peroxide lactone derived from a traditional Chinese herbal remedyArtemisia annuaL., to enhance the solubility and antimalarial activity of its parental compound. Artemether exhibits potent antimalarial and antischistosomal activities against malarial parasites andSchistosoma japonicuminfections. Although it has not been well elucidated, an endoperoxide bridge within the chemical structure of Artemether might be the key characteristic considered to be responsible for its antimalarial and antischistosomal activities, which can be metabolized by malarial or schistosomal parasites, underin vivoconditions, generating detrimental oxygen radicals to attack parasite macromolecules. Reference [1].Xiao Shuhua and Brian A. Catto. In vitro and in vivo studies of the effect of artemether on Schistosoma mansoni. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 1989, 1557-1562 |
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