Pyr3

立即咨询

Pyr3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1160514-60-2

包装与价格：

包装	价格(元)
5mg	询价
10mg	询价

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	456.63
Cas No.	1160514-60-2
Formula	C₁₆H₁₁Cl₃F₃N₃O₃
Solubility	Soluble in DMSO
Chemical Name	ethyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
Canonical SMILES	Cl/C(C(NC1=CC=C(C=C1)N2N=CC(C(OCC)=O)=C2C(F)(F)F)=O)=C(Cl)\Cl
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Pyr3, a pyrazole compound, selectively inhibits the canonical transient receptor potential channel 3 (TRPC3) [1].

TRPC3 is a member of TRPCs which control influxes of Ca²⁺ and other cations that induce diverse cellular processes upon stimulation of plasma membrane receptors coupled to phospholipase C. TRPC3 has been implicated in diverse biological functions, including B cell receptor-mediated Ca²⁺ oscillations, T cell receptor-dependent Ca²⁺ entry pathway, and cardiac hypertrophy [1].

In HEK293 cells, Pyr3 selectively inhibited TRPC3-mediated Ca²⁺ influx in a dose-dependent manner, with an IC50 value of 0.7 μM. In rat neonatal cardiomyocytes, Pyr3 suppressed activation of nuclear factor of activated T cells, with an IC50 value of 0.05 μM [1].

In sham operated mice, chronic treatment with Pyr3 (0.1 mg·kg^–1·day^–1, i.p.), Pyr3 attenuatedin vivo pressure overload-induced cardiac hypertrophy. In addition, the transverse aortic constriction operation-induced increase in expression of atrial natriuretic peptide mRNA, a reliable marker for cardiac hypertrophy, was also suppressed by Pyr3 [1].

Reference:

[1]. Kiyonaka S, Kato K, Nishida M, et al. Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proceedings of the National Academy of Sciences of the United States of America, 2009, 106(13): 5400-5405.