Tin protoporphyrin IX dichloride

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CAS NO:

14325-05-4

包装与价格：

包装	价格(元)
10mg	询价
25mg	询价
50mg	询价

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	750.25
Cas No.	14325-05-4
Formula	C₃₄H₃₂Cl₂N₄O₄Sn
Solubility	insoluble in EtOH; insoluble in H2O; ≥22.15 mg/mL in DMSO
Canonical SMILES	C=CC1=C(/C2=C([H])/C(C(C)=C/3CCC([O-])=O)=NC3=C([H])/C4=N/C(C(C)=C4CCC([O-])=O)=C([H])\C5=C(C(C)=C([N-]5)/C([H])=C1\[N-]2)C=C)C.Cl.Cl.[Sn+4]
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Tin protoporphyrin IX dichloride is a synthetic heme analog that selectively inhibits heme oxygenase 2 (HO-2) with IC50 value of 7.5 μM [1].

HO-2, widely expressed with high concentrations in the brain, is one of two forms of HO (HO-1 and HO-2). HO is responsible for converting heme to biliverdin, and carbon monoxide (CO), which has been implicated as a biological messenger molecule analogous to nitric oxide (NO) with endothelial-derived relaxing activity [1].

Tin protoporphyrin IX dichloride is a selective inhibitor of HO with ~ 10-fold selectivity for HO over endothelial nitric oxide synthase (NOS) and soluble guanylyl cyclase (IC50s = 35 and 30 nM, respectively). Tin protoporphyrin IX dichloride (1 ~ 100 μM) reduced acetylcholine (Ach)-induced endothelial-derived relaxation of porcine distal pulmonary arteries in the presence ofN^w-nitro-Larginine methyl ester (L-NAME), with an IC50 of 7.6 μM [1].

In Sprague-Dawley rat neonates, a single subcutaneous injection of Tin protoporphyrin IX dichloride (100 μmol/kg) at birth, 12, 24, 48, and 72 hr later, blocked the postnatal increase in heme oxygenase activity that occurs in various tissues. Tin protoporphyrin IX dichloride administration also entirely prevented the development of hyperbilirubinemia that normally occurs postnatally [2].

References:

[1]. Zakhary R, Gaine S P, Dinerman J L, et al. Heme oxygenase 2: Endothelial and neuronal localization and role in endothelium-dependent relaxation. Proceedings of the National Academy of Sciences of the United States of America, 1996, 93(2): 795-798.

[2]. Drummond G S, Kappas A. Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation. Proceedings of the National Academy of Sciences of the United States of America, 1981, 78(10): 6466-6470.