| 产品描述 | Fenbendazole-d3is intended for use as an internal standard for the quantification of fenbendazole by GC- or LC-MS. Fenbendazole is a benzimidazole anthelmintic.1It is active againstGiardia in vitro(IC50= 0.3 μM). Fenbendazole (20 mg/kg) prevents infiltration of parasites into the brain in a rabbit model ofE. cuniculiinfection.2It also activates HIF-1α and prevents oxidative stress-induced death in primary neuronsin vitro.3 1.Morgan, U.M., Reynoldson, J.A., and Thompson, R.C.A.Activities of several benzimidazoles and tubulin inhibitors against Giardia spp. in vitroAntimicrob. Agents Chemother.37(2)328-331(1993)
2.Suter, C., MÜller-Doblies, U.U., Hatt, J.-M., et al.Prevention and treatment of Encephalitozoon cuniculi infection in rabbits with fenbendazoleVet. Rec. 148(15)478-480(2001)
3.Aleyasin, H., Karuppagounder, S.S., Kumar, A., et al.Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulinAntioxid. Redox Signal.22(2)121-134(2015) |
