噻洛芬酸是一种具有抗炎和镇痛功效的口服活性非甾体抗炎药 (NSAID)。
| Cas No. | 33005-95-7 |
| 别名 | 噻洛芬酸 |
| Canonical SMILES | O=C(C1=CC=C(C(C)C(O)=O)S1)C2=CC=CC=C2 |
| 分子式 | C14H12O3S |
| 分子量 | 260.3 |
| 溶解度 | DMF: 15mg/mL,DMSO: 20mg/mL,Ethanol: 20mg/mL,Ethanol:PBS (pH 7.2) (1:10): 0.09mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Tiaprofenic acid is a COX inhibitor and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic activities.1 It inhibits synthesis of prostaglandin E2 and PGF2α from arachidonic acid in bovine seminal vesicle microsomes and inhibits thromboxane B2 formation in human umbilical cord arteries bathed in clotting human blood (IC50 = 0.71 μM).2,1 Tiaprofenic acid has anti-inflammatory activity in rat models of carrageenan-induced edema and adjuvant-induced arthritis and has analgesic activity in acetic acid- or phenylquinone-induced writhing tests in rodents.1 References
1. Sorkin, E.M., and Brogden, R.N. Tiaprofenic acid. A review of its pharmacological properties and therapeutic efficacy in rheumatic diseases and pain states. Drugs 29(3), 208-235 (1985).
2. Schr•r, K., and Seidel, H. Blood-vessel wall arachidonate metabolism and its pharmacological modification in a new in vitro assay system. Naunyn Schmiedebergs Arch. Pharmacol. 337(2), 177-182 (1988). |
