Verinurad (RDEA3170) 是一种高效且特异性的 URAT1 抑制剂，IC50 为 25 nM。
| Cas No. | 1352792-74-5 |
| 别名 | 维立诺雷; RDEA3170 |
| Canonical SMILES | CC(C)(SC1=C(C2=C3C=CC=CC3=C(C#N)C=C2)C=NC=C1)C(O)=O |
| 分子式 | C20H16N2O2S |
| 分子量 | 348.42 |
| 溶解度 | DMSO : ≥ 30 mg/mL (86.10 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Verinurad is an urate transporter inhibitor with EC50 value of 0.05 uM.IC50 value: 0.05 uM (EC50)Target: urate transporterVerinurad is useful in the modulation of blood or serum uric acid levels, reducing serum uric acid levels in a human. References:
[1]. Yeh Li-Tain, et al. 3,4-Di-substituted pyridine compound, methods of use and compositions comprising the same. From PCT Int. Appl. (2013), WO 2013067425 A1 20130510.
[2]. Ouk, Samedy, et al. Thioacetate compounds as URAT-1 agonists and their preparation, compositions and methods of use. From PCT Int. Appl. (2011), WO 2011159839 A2 20111222. |
