L-Thyroxine

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L-Thyroxine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

51-48-9

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	询价
500mg	询价
1g	询价

化学性质

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	776.87
Cas No.	51-48-9
Formula	C₁₅H₁₁I₄NO₄
Solubility	≥27.35 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
Chemical Name	(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
Canonical SMILES	IC(C=C(C=C1I)C[C@@H](C(O)=O)N)=C1OC(C=C2I)=CC(I)=C2O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

L-Thyroxine is an iodine containing hormone produced from thyroglobulin in the thyroid follicular cells. L-Thyroxine reduces total cholesterol level, low-density lipoprotein cholesterol as well as waist to hip ratio in subclinical hypothyroidism pateints.

试验操作

Animal experiment:[1]
Animal models	Weanling mice of the Swiss-Webster strain
Dosage form	0.9 or 2.7 μg Administered subcutaneously 2 hours before the administration of purified porcine thyrotropin-releasing factor (TRF)
Applications	L-Thyroxine inhibited synthesis and release of thyrotropin (TSH) induced by TRF from the anterior pituitary in mice. Complete inhibition of the TRF-TSH release response was achieved with 2.7 μg L-thyroxine and partial inhibition occurred with 0.9 μg L-thyroxine. The inhibition caused by L-thyroxine could be overcame by increasing the dose of TRF.
Note	The technical data provided above is for reference only.
	References: 1. Bowers CY, Schally AV, Reynolds GA, et al. Interactions of L-thyroxine or L-triiodothyronine and thyrotropin-releasing factor on the release and synthesis of thyrotropin from the anterior pituitary gland of mice. Endocrinology, 1967, 81(4): 741-747.