首页 蛋白库 基因库 产品 会员服务
位置：首页 > 产品库 > Boc-gly-PEG3-endo-BCN
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Boc-gly-PEG3-endo-BCN
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Boc-gly-PEG3-endo-BCN图片
CAS NO:2110444-63-6
包装:100mg
市场价:10232元

Boc-gly-PEG3-endo-BCN 是一种 PROTAC linker，属于 PEG 类。可用于合成PROTAC分子。Boc-gly-PEG3-endo-BCN 也是一种可降解 (cleavable) 的含 2 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。
Cas No.2110444-63-6
分子式C28H47N3O8
分子量553.69
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Boc-gly-PEG3-endo-BCN is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-gly-PEG3-endo-BCN is also a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
[2]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024