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17α-hydroxy Pregnenolone
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
17α-hydroxy Pregnenolone图片
CAS NO:387-79-1
包装与价格：
包装价格(元)
100mg询价
250mg询价
500mg询价
1g询价

1&7#945;-羟基孕烯醇酮是一种孕烷类固醇。
Cas No.387-79-1
别名17α-羟基妊娠烯醇酮,NSC 63853
化学名3β,17-dihydroxy-pregn-5-en-20-one
Canonical SMILESO[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(C)=O
分子式C21H32O3
分子量332.5
溶解度DMF: 0.5mg/mL,DMF:PBS (7.2) (1:1.5): 0.4mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

17α-hydroxy Pregnenolone is a metabolite of pregnenolone and a precursor in the biosynthesis of dehydroepiandrosterone .[1] It is formed from pregnenolone by cytochrome P450 (CYP) isoform CYP17A1 hydroxylase activity and then converted to dehydroepiandrosterone by CYP17A1-mediated 17,20-lyase activity. Plasma levels of 17α-hydroxy pregnenolone are elevated in patients with type II 3β-hydroxysteroid dehydrogenase deficiency, a form of congenital adrenal hyperplasia.[2]

Reference:
[1]. Petrunak, E.M., DeVore, N.M., Porubsky, P.R., et al. Structures of human steroidogenic cytochrome P450 17A1 with substrates. J. Biol. Chem. 289(47), 32952-32964 (2014).
[2]. Fiet, J., Giton, F., Boudi, A., et al. Plasma 17-OH pregnenolone: Comparison of a time-resolved fluoroimmunoassay using a new tracer 17-OH pregnenolone-3-oxyacetyl-biotine with a radioimmunoassay using 125I 17-OH pregnenolone-3-hemisuccinate-histamine. Steroids 66(2), 81-86 (2001).

 
 
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