Hinokiflavone，是 pre-mRNA 剪接活性的一种新型调节剂，在体内外均有效。 Hinokiflavone 通过抑制剪接体装配来阻止前 mRNA 底物的剪接，特别是阻止 B complex 的形成。Hinokiflavone是 SUMO protease 蛋白酶抑制剂，可抑制前哨蛋白特异性蛋白酶 1 (SENP1) 的活性
| Cas No. | 19202-36-9 |
| 别名 | 扁柏双黄酮 |
| Canonical SMILES | O=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O)=C(OC4=CC=C(C5=CC(C6=C(O)C=C(O)C=C6O5)=O)C=C4)C(O)=C13 |
| 分子式 | C30H18O10 |
| 分子量 | 538.46 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Hinokiflavone is a novel modulator of pre-mRNA splicing activity in vitro and in cellulo. Hinokiflavone blocks splicing of pre-mRNA substrates by inhibiting spliceosome assembly, specifically preventing B complex formation. Hinokiflavone is a SUMO protease inhibitor, inhibiting sentrin-specific protease 1 (SENP1) activity[1]. [1]. Pawellek A, et al. Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP. Elife. 2017 Sep 8;6. pii: e27402. |
